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Novel mode of action

ENTRESTO simultaneously enhances the beneficial vasculatory effects of the natriuretic peptide system whilst inhibiting the detrimental effects of the renin–angiotensin–aldosterone system.1




  1. Vardeny O, et al. Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure CME. J Am Coll Cardiol Heart Fail 2014;2(6):663–670.

Date of preparation: July 2016 ENT16-C022c(1)